Synthesis and antitumor-evaluation of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives

被引：45

作者：

Zhao, Hai-Chuan ^{[1
]}

Shi, Yan-Ping ^{[1
]}

Liu, Yu-Ming ^{[1
]}

Li, Cai-Wen ^{[1
]}

Xuan, Li-Na ^{[1
]}

Wang, Peng ^{[1
]}

Zhang, Kai ^{[1
]}

Chen, Bao-Quan ^{[1
]}

机构：

[1] Tianjin Univ Technol, Dept Chem & Chem Engn, Tianjin 300384, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 24期

基金：

中国国家自然科学基金;

关键词：

1,3-Selenazole; 1,3,4-Thiadiazole derivatives; Schiff base; Antitumor agents; IN-VITRO; INHIBITOR;

D O I：

10.1016/j.bmcl.2013.10.062

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel 1,3-selenazole-containing 1,3,4-thiadiazole derivatives bearing Schiff base moieties were synthesized and evaluated for their in vitro antiproliferative activities against human breast cancer cell MCF-7 and mouse lymphocyte leukemia cell L1210 by CCK-8 assay. The majority of the compounds showed better activity against MCF-7 cell, compared with lead compound PCS. In particular, compound 6c was the most potent compound with IC50 value of 4.02 mu M. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6577 / 6579

页数：3

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