The role of protective CD8+T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: regulatory vs. lytic

被引：8
|
作者：
Nicholson, SM [1 ]
Haynes, LM [1 ]
Vanderlugt, CL [1 ]
Miller, SD [1 ]
Melvold, RW [1 ]
机构：
[1] Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 98卷 / 02期
关键词：
mouse; T lymphocytes; TMEV; neuroimmunology; EAE/MS;
D O I：
10.1016/S0165-5728(99)00090-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8(+) splenic T cells from resistant BALE/cByJ donors protect irradiated BALB/cByJ, as well as BALB/cAnNCr recipients, from development of TMEV-IDD. Anti-TMEV CTL activities in BALB/cAnNCr, BALB/cByJ and irradiated BALB/cByJ mice are comparable. A population of splenic CD4(+) T cells in BALB/cByJ donors has also been identified which can protect both susceptible BALB/cAnNCr and irradiated BALB/cByJ recipients from TMEV-IDD via adoptive transfer. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：136 / 146
页数：11
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