NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

被引：29

作者：

Frame, Margaret C. ^{[1
]}

Inman, Gareth J. ^{[2
]}

机构：

[1] Western Gen Hosp, Inst Genet & Mol Med, Edinburgh Canc Res Ctr, Edinburgh EH4 2XR, Midlothian, Scotland

[2] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

DEVELOPMENTAL CELL | 2008年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.devcel.2008.09.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

引用

页码：494 / 496

页数：3

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