Delaying a Treatment Switch in Antiretroviral-Treated HIV Type 1-Infected Patients with Detectable Drug-Resistant Viremia Does Not Have a Profound Effect on Immune Parameters: AIDS Clinical Trials Group Study A5115

被引：4

作者：

Tenorio, Allan R. ^{[1
]}

Jiang, Hongyu ^{[2
]}

Zheng, Yu ^{[2
]}

Bastow, Barbara ^{[3
]}

Kuritzkes, Daniel R. ^{[4
,5
]}

Bartlett, John A. ^{[6
]}

Deeks, Steven G. ^{[7
,8
]}

Landay, Alan L. ^{[9
]}

Riddler, Sharon A. ^{[10
]}

机构：

[1] Rush Univ, Med Ctr, Dept Med, Rush Med Coll, Chicago, IL 60612 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Biostat, Stat & Data Anal Ctr, Boston, MA 02319 USA

[3] Social & Sci Syst Inc, Silver Spring, MD 20910 USA

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Sect Retroviral Therapeut, Boston, MA 02319 USA

[5] Harvard Univ, Sch Med, Div Aids, Boston, MA 02319 USA

[6] Duke Univ, Med Ctr, Dept Med, Durham, NC 27706 USA

[7] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[8] Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco, CA 94143 USA

[9] Rush Med Coll, Dept Immunol & Microbiol, Chicago, IL 60612 USA

[10] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15260 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2009年 / 25卷 / 02期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTED PATIENTS; VIROLOGICAL FAILURE; THERAPY; ACTIVATION; RESPONSES; RISK; INDIVIDUALS; PROGRESSION; MITOGEN;

D O I：

10.1089/aid.2008.0200

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Some patients are unable to achieve and maintain an undetectable plasma HIV-1 RNA level with combination antiretroviral therapy (ART) and are therefore maintained on a partially suppressive regimen. To determine the immune consequences of continuing ART despite persistent viremia, we randomized 47 ART-treated individuals with low to moderate plasma HIV-1 RNA levels (200-9999 copies/ml) to either an immediate switch in therapy or a delayed switch (when plasma HIV-1 RNA became >= 10,000 copies/ml). After 48 weeks of follow-up, naive and memory CD4(+) T cell percents were comparable in the two groups. The proportion of subjects with a lymphocyte proliferative response to Candida, Mycobacterium avium-intracellulare complex, or HIV-gag was also not significantly different at week 48. Delaying a treatment switch in patients with partial virologic suppression and stable CD4(+) T cells does not have profound effects on immune parameters.

引用

页码：135 / 139

页数：5