Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

被引：152
|
作者：
Wensink, G. Emerens [1 ]
Elias, Sjoerd G. [2 ]
Mullenders, Jasper [3 ]
Koopman, Miriam [1 ]
Boj, Sylvia F. [3 ]
Kranenburg, Onno W. [4 ,5 ]
Roodhart, Jeanine M. L. [1 ]
机构：
[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Med Oncol, Utrecht, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidmiol, Utrecht, Netherlands
[3] Fdn Hubrecht Organoid Technol HUB, Utrecht, Netherlands
[4] Univ Utrecht, Univ Med Ctr Utrecht, Dept Surg Oncol, Utrecht, Netherlands
[5] Univ Utrecht, Univ Med Ctr Utrecht, Utrecht Platform Organoid Technol, Utrecht, Netherlands
来源：
NPJ PRECISION ONCOLOGY | 2021年 / 5卷 / 01期
关键词：
D O I：
10.1038/s41698-021-00168-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Effective predictive biomarkers are needed to enable personalized medicine and increase treatment efficacy and survival for cancer patients, thereby reducing toxic side effects and treatment costs. Patient-derived organoids (PDOs) enable individualized tumour response testing. Since 2018, 17 publications have examined PDOs as a potential predictive biomarker in the treatment of cancer patients. We review and provide a pooled analysis of the results regarding the use of PDOs in individualized tumour response testing, focusing on evidence for analytical validity, clinical validity and clinical utility. We identify future perspectives to accelerate the implementation of PDOs as a predictive biomarker in the treatment of cancer patients.
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页数：13
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