In Vitro Antibacterial Activity of Phx-3 against Helicobacter pylori

被引：13
|
作者：
Hanawa, Tomoko [1 ]
Osaki, Takako [1 ]
Manzoku, Taki [4 ]
Fukuda, Minoru [2 ]
Kawakami, Hayato [3 ]
Tomoda, Akio [5 ]
Kamiya, Shigeru [1 ]
机构：
[1] Kyorin Univ, Sch Med, Dept Infect Dis, Div Med Microbiol, Tokyo 1818611, Japan
[2] Kyorin Univ, Sch Med, Electron Microscopy Lab, Tokyo 1818611, Japan
[3] Kyorin Univ, Sch Med, Dept Biochem, Dept Anat 2, Tokyo 1818611, Japan
[4] Miyarisan Pharmaceut Co Ltd, Kita Ku, Tokyo 1140016, Japan
[5] Tokyo Med Univ, Shinjuku Ku, Tokyo 1608402, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2010年 / 33卷 / 02期
关键词：
Helicobacter pylori; phenoxazine; bactericidal agent; CLARITHROMYCIN; LANSOPRAZOLE; ANTIBIOTICS; ACTINOMYCIN; AMOXICILLIN; INHIBITION; POLIOVIRUS;
D O I：
10.1248/bpb.33.188
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Phx-3, one of the phenoxazine derivatives, is reported to have inhibitory effect on Mycobacterium species and Chlamydia pneumoniae but not Escherichia coli, Salmonella Typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, Listeria monocytogenes. The bactericidal activities of Phx-3 against Helicobacter pylori strains have not been assessed. Then, we measured minimum inhibitory concentration of Phx-3 for Helicobacter strains and assessed the morphological and biochemical effects of Phx-3 on H. pylori. In present study, it has shown that H. pylori strains including clarithromycin resistant strain and Helicobacter musterae were killed effectively by the treatment with Phx-3. Furthermore, severe morphological changes such as membrane blebbing and formation of hollows in H. pylori were detected. In addition, induction of heat shock protein 60 was observed. Taken together, Phx-3 has antibacterial activity against Helicobacter pylori.
引用
收藏
页码：188 / 191
页数：4
相关论文
共 50 条
  • [1] In vitro antibacterial activity of nimbolide against Helicobacter pylori
    Wylie, Marina R.
    Windham, Ian H.
    Blum, Faith C.
    Wu, Hannah
    Merrell, D. Scott
    JOURNAL OF ETHNOPHARMACOLOGY, 2022, 285
  • [2] In vitro antibacterial activity of Chilean propolis against Helicobacter pylori
    Villanueva, Maria
    Gonzalez, Mario
    Fernandez, Heriberto
    Wilson, Myra
    Manquian, Nimia
    Otth, Carola
    Otth, Laura
    REVISTA CHILENA DE INFECTOLOGIA, 2015, 32 (05): : 536 - 539
  • [3] In vitro antibacterial activity of clarithromycin and omeprazole against Helicobacter pylori.
    Schwalbe, R
    Morris, JG
    Fantry, GT
    GASTROENTEROLOGY, 1996, 110 (04) : A254 - A254
  • [4] In vitro antibacterial activity of Chilean red wines against Helicobacter pylori
    Daroch, F
    Hoeneisen, M
    González, CL
    Kawaguchi, F
    Salgado, F
    Solar, H
    García, A
    MICROBIOS, 2001, 104 (408) : 79 - 85
  • [5] In Vitro Antibacterial Activity of Acyl-Lysyl Oligomers against Helicobacter pylori
    Makobongo, Morris O.
    Kovachi, Tchelet
    Gancz, Hanan
    Mor, Amram
    Merrell, D. Scott
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (10) : 4231 - 4239
  • [6] Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one (Phx-3): Direct and Indirect Anti-Cancer Activity of Phx-3
    Tomoda, Akio
    Miyazawa, Keisuke
    Tabuchi, Takafumi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (09) : 17573 - 17583
  • [7] Antibacterial activity of Humulus lupulus against Helicobacter pylori
    Matos, R
    Vasconcelos, L
    Oleastro, M
    Monteiro, L
    GUT, 2001, 49 : A5 - A5
  • [8] In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori
    Hajimahmoodi, M.
    Shams-Ardakani, M.
    Saniee, P.
    Siavoshi, F.
    Mehrabani, M.
    Hosseinzadeh, H.
    Foroumadi, P.
    Safavi, M.
    Khanavi, M.
    Akbarzadeh, T.
    Shafiee, A.
    Foroumadi, A.
    NATURAL PRODUCT RESEARCH, 2011, 25 (11) : 1059 - 1066
  • [9] In vitro antibacterial activity of amoxicillin, clarithromycin, metronidzole, and tinidazole against Helicobacter pylori.
    Nakayama, I
    Yamaji, E
    Yoshikawa, E
    GASTROENTEROLOGY, 1997, 112 (04) : A231 - A231
  • [10] Antibacterial activity of Trachyspermum copticum against Helicobacter pylori
    Nariman, F.
    Eftekhar, F.
    Massarrat, S.
    Habibi, Z.
    Malekzadeh, R.
    HELICOBACTER, 2006, 11 (04) : 323 - 323
12345