Intramolecular microsolvation of SN2 transition states

被引：42

作者：

Craig, SL ^{[1
]}

Brauman, JI ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 28期

关键词：

D O I：

10.1021/ja983010x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introduction of an omega-substituent (CN, Cl, or OH) onto a primary n-alkyl chloride significantly enhances the rate of S(N)2 chloride exchange in the gas phase. Trends in reactivity suggest that the rate acceleration depends primarily on through-space solvation of the transition state, especially charge-dipole interactions. The potential energy surfaces and dynamics of these reactions are discussed.

引用

页码：6690 / 6699

页数：10

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