Synthesis of (1S,2S)- and (1R,2S)-3-amino-1,2-dihydroxypropylphosphonic acids

被引：0

作者：

Wróblewski, AE ^{[1
]}

Glowacka, IE ^{[1
]}

机构：

[1] Med Univ Lodz, Fac Pharm, Bioorgan Chem Lab, PL-90151 Lodz, Poland

来源：

POLISH JOURNAL OF CHEMISTRY | 2005年 / 79卷 / 12期

关键词：

3-aminophosphonic acids; 1-hydroxyphosphonates; configuration; conformation;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(1S,2S)- and (1R,2S)-3-amino-1,2-dihydroxypropylphosphonic acids were synthesized from (S)-3-azido-2-benzyloxypropanal in two steps, which involved addition of dibenzyl phosphite, clean separation of dibenzyl (1S,2S)- and (1R,2S)-3-azido-2-benzyloxy-1-hydroxypropylphosphonates followed by azide reduction with simultaneous hydrogenolysis of benzyl protecting groups.

引用

页码：1895 / 1899

页数：5

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