The prognostic value of tumour-stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review

被引：69
|
作者：
Kramer, C. J. H. [1 ]
Vangangelt, K. M. H. [1 ]
van Pelt, G. W. [1 ]
Dekker, T. J. A. [1 ]
Tollenaar, R. A. E. M. [1 ]
Mesker, W. E. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Surg, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
来源：
BREAST CANCER RESEARCH AND TREATMENT | 2019年 / 173卷 / 01期
关键词：
Breast cancer; Triple-negative breast cancer; Tumour-stroma ratio; Prognosis; Review; DISEASE-FREE SURVIVAL; INDEPENDENT PREDICTOR; PERIOPERATIVE CHEMOTHERAPY; INFILTRATING LYMPHOCYTES; COLORECTAL-CANCER; VALIDATION; EXPRESSION; CARCINOMA; RECURRENCE; RESECTION;
D O I：
10.1007/s10549-018-4987-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PurposeThere is a strong need to improve the prognostication of breast cancer patients in order to prevent over- and undertreatment, especially when considering adjuvant chemotherapy. Tumour stroma characteristics might be valuable in predicting disease progression.MethodsStudies regarding the prognostic value of tumour-stroma ratio (TSR) in breast cancer are evaluated.ResultsA high stromal content is related to a relatively poor prognosis. The most pronounced prognostic effect of this parameter seems to be observed in the triple-negative breast cancer (TNBC) subtype.ConclusionsTSR assessment might represent a simple, fast and reproducible prognostic factor at no extra costs, and could possibly be incorporated into routine pathological diagnostics. Despite these advantages, a robust clinical validation of this parameter has yet to be established in prospective studies.
引用
收藏
页码：55 / 64
页数：10
相关论文
共 50 条
  • [1] The prognostic value of tumour–stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review
    C. J. H. Kramer
    K. M. H. Vangangelt
    G. W. van Pelt
    T. J. A. Dekker
    R. A. E. M. Tollenaar
    W. E. Mesker
    Breast Cancer Research and Treatment, 2019, 173 : 55 - 64
  • [2] The prognostic value of tumour-stroma ratio in triple-negative breast cancer
    Moorman, A. M.
    Vink, R.
    Heijmans, H. J.
    van der Palen, J.
    Kouwenhoven, E. A.
    EJSO, 2012, 38 (04): : 307 - 313
  • [3] The Prognostic Value of Tumour-stroma Ratio in Triple Negative Breast Cancer
    Moorman, A. M.
    Vink, R.
    Heijmans, H. J.
    van der Palen, J.
    Kouwenhoven, E. A.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S369 - S369
  • [4] The Prognostic Value of Tumour-Stroma Ratio in Triple Negative Breast Cancer.
    Moorman, A. M.
    Vink, R.
    Heijmans, H. J.
    van der Palen, J.
    Kouwenhoven, E. A.
    CANCER RESEARCH, 2011, 71
  • [5] The prognostic value of the tumour-stroma ratio validates in subgroups of breast cancer, especially in grade III tumours
    Mesker, W.
    Vangangelt, K.
    Green, A.
    Heemskerk, I.
    Cohen, D.
    Putter, H.
    Rakha, E.
    Tollenaar, R.
    VIRCHOWS ARCHIV, 2019, 475 : S15 - S15
  • [6] The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study
    Roeke, Toni
    Sobral-Leite, Marcelo
    Dekker, Tim J. A.
    Wesseling, Jelle
    Smit, Vincent T. H. B. M.
    Tollenaar, Rob A. E. M.
    Schmidt, Marjanka K.
    Mesker, Wilma E.
    BREAST CANCER RESEARCH AND TREATMENT, 2017, 166 (02) : 435 - 445
  • [7] The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study
    Toni Roeke
    Marcelo Sobral-Leite
    Tim J. A. Dekker
    Jelle Wesseling
    Vincent T. H. B. M. Smit
    Rob A. E. M. Tollenaar
    Marjanka K. Schmidt
    Wilma E. Mesker
    Breast Cancer Research and Treatment, 2017, 166 : 435 - 445
  • [8] The prognostic value of the tumour-stroma ratio in invasive breast carcinoma
    Mesker, W. E.
    Vangangelt, K.
    Tollenaar, L.
    van Pelt, G.
    Dekker, T.
    Kuppen, P.
    Tollenaar, R.
    VIRCHOWS ARCHIV, 2018, 473 : S52 - S52
  • [9] The prognostic value of the tumour-stroma ratio in invasive breast carcinoma
    Mesker, W. E.
    Vangangelt, K.
    Tollenaar, R.
    EUROPEAN JOURNAL OF CANCER, 2018, 92 : S48 - S48
  • [10] Prognostic value of tumour-stroma ratio in colorectal carcinomas
    Hmidi, A.
    Khanchel, F.
    Helal, I.
    Ben Thayer, M.
    Ben Brahim, E.
    Chadli-Debbiche, A.
    VIRCHOWS ARCHIV, 2021, 479 (SUPPL 1) : S87 - S88
12345