Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing

被引：2
|
作者：
Wood, PJ
IoannidesDemos, LL
Bastone, EB
Spicer, WJ
McLean, AJ
机构：
[1] ALFRED HEALTHCARE GRP,DEPT CLIN PHARMACOL,PRAHRAN,VIC 3181,AUSTRALIA
[2] ALFRED HEALTHCARE GRP,DEPT PHARM,PRAHRAN,VIC 3181,AUSTRALIA
[3] ALFRED HEALTHCARE GRP,DEPT MICROBIOL & INFECT DIS,PRAHRAN,VIC 3181,AUSTRALIA
[4] ALFRED HEALTHCARE GRP,DEPT MED,PRAHRAN,VIC 3181,AUSTRALIA
[5] MONASH UNIV,ALFRED HEALTHCARE GRP,DEPT MICROBIOL,PRAHRAN,VIC 3181,AUSTRALIA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 05期
关键词：
D O I：
10.1128/AAC.40.5.1321
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pseudomonas aeruginosa ATCC 27853 was exposed to tobramycin concentration-time profiles modelling in vivo bolus and infusion dosing, Dependence of bactericidal and bacteriostatic activity on the initial profile of peak concentration (bolus effect > infusion) and area under the antibiotic concentration-time curve was observed at peak concentration/MIC ratios of 10 or below.
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页码：1321 / 1324
页数：4
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