NUMERICAL STUDY OF A TRANSIENT GAS AND PARTICLE FLOW IN A HIGH-SPEED NEEDLE-FREE BALLISTIC PARTICULATE VACCINE DELIVERY SYSTEM

被引：15
|
作者：
Liu, Y. [1 ]
Kendall, M. A. F. [1 ]
机构：
[1] Univ Oxford, Dept Engn Sci, PowderJect Ctr Gene & Drug Delivery Res, Oxford OX2 6PE, England
来源：
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY | 2004年 / 4卷 / 04期
关键词：
Biolistics; gene gun; nozzle; numerical; supersonic;
D O I：
10.1142/S0219519404001132
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A unique biolistic method of vaccination is operated by accelerating particulate vaccines with a high-speed gas jet generated by a convergent-divergent conical nozzle to sufficient momentum to penetrate the outer layer of human skin. The targeted cells elicit an immunological response. In this paper, Computational Fluid Dynamics (CFD) is utilized to simulate the operation of a prototype biolistics delivery system. The key features of transient gas dynamics and gas-particle interaction are discussed.
引用
收藏
页码：559 / 578
页数：20
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