Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice

被引：0
|
作者：
Chen, Xiaoqiang [1 ,2 ]
Ye, Sudan [3 ]
Zhang, Shikang [2 ]
Li, Jianrong [1 ]
Zhu, Hongying [4 ]
Zheng, Gaoli [5 ]
Lu, Yin [4 ]
Wan, Haitong [6 ]
机构：
[1] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China
[2] China COOP, Hangzhou Tea Res Inst, Hangzhou 310016, Zhejiang, Peoples R China
[3] Zhejiang Econ & Trade Polytech, Hangzhou 310018, Zhejiang, Peoples R China
[4] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Zhejiang, Peoples R China
[5] Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou 310013, Zhejiang, Peoples R China
[6] Zhejiang Chinese Med Univ, Inst Cardiocerebrovasc Dis, Hangzhou 310035, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 05期
基金：
美国国家科学基金会;
关键词：
FTY720; type 1 diabetes (T1D); non-obese diabetic (NOD) mice; physiological indexes; IMMUNOSUPPRESSIVE AGENT; GRAFT-SURVIVAL; PREVENTION; MODEL; RAT; TRANSPLANTATION; DISEASE;
D O I：
10.3390/ijms13056129
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P < 0.01). The result of tests of anti-GAD antibody suggested that FTY720 treatment could suppress the anti-GAD response.
引用
收藏
页码：6129 / 6137
页数：9
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