Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics

被引：91
|
作者：
Bryan, Christopher S. [1 ]
Lautens, Mark [1 ]
机构：
[1] Univ Toronto, Dept Chem, Davenport Labs, Toronto, ON M5S 3H6, Canada
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 20期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1021/ol801932z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald-Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts.
引用
收藏
页码：4633 / 4636
页数：4
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