Sm(III)-catalyzed highly diastereoselective rearrangement and reduction of α-hydroxy epoxides -: A new synthetic method for preparing 1,3-diol monoesters

被引：0
|
作者：
Fan, CA [1 ]
Song, ZL [1 ]
Tu, YQ [1 ]
Wang, BM [1 ]
机构：
[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Dept Chem, Lanzhou 730000, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 21卷 / 11期
关键词：
diastereoselectivity; 1,3-diol; alpha-hydroxy epoxide; samarium diiodide; tandem reaction;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Anew Sm(III)-catalyzed tandem reaction of a-hydroxy epoxide has been discovered, where two catalytic reactions occur sequentially in one-pot and afford three contiguous stereocenters in a highly diastereoselective manner. It could be developed to a general procedure for diastereoselective construction of 2-quaternary-1,3-diol units. Extensive investigations of the reaction conditions and mechanism are also described.
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页码：1074 / 1080
页数：7
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