FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2

被引：1
|
作者：
Wiwanitkit, Viroj [1 ]
机构：
[1] Wiwanitkit House, Bangkok 10160, Thailand
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2009年 / 277卷 / 1-2期
关键词：
Familial hemiplegic migraine; Mutation;
D O I：
10.1016/j.jns.2008.10.012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM. Here, a bioinformatics analysis was done to study the risk positions for mutation within the amino acid sequence of the three mentioned molecules. In this work, the author can identify many mutant prone positions within the studied FHM. Of interest, the author detected that FHM3 is a high resistant molecule when compared to FHM1 and FHM2. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：76 / 79
页数：4
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