Phytochemical characterization of phenolics by LC-MS/MS and biological evaluation of Ajuga orientalis from Turkey

被引：24

作者：

Goger, Fatih ^{[1
]}

Kose, Yavuz Bulent ^{[2
]}

Goger, Gamze ^{[1
,3
]}

Demirci, Fatih ^{[1
,4
]}

机构：

[1] Anadolu Univ, Fac Pharm, Dept Pharmacognosy, TR-26470 Eskisehir, Turkey

[2] Anadolu Univ, Fac Pharm, Dept Pharmaceut Bot, TR-26470 Eskisehir, Turkey

[3] Anadolu Univ, Grad Sch Hlth Sci, TR-26470 Eskisehir, Turkey

[4] Anadolu Univ, Fac Hlth Sci, TR-26470 Eskisehir, Turkey

来源：

BANGLADESH JOURNAL OF PHARMACOLOGY | 2015年 / 10卷 / 03期

关键词：

ANTIMICROBIAL ACTIVITIES; ANTIOXIDANT; L; GLYCOSIDES; PLANTS;

D O I：

10.3329/bjp.v10i3.23500

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to reveal the phytochemical constituents, antioxidant and antimicrobial activity of Ajuga orientalis. According to the antimicrobial results, the methanol extract of A. orientalis showed a MIC value of 312.5 mu g/mL against the tested pathogenic bacterial strains. Anticandidal activity of extract was found as 156.3 mu g/mL both against Candida albicans and C. parapsilosis strains. Whereas the extract was more effective against C. tropicalis with the MIC value of 78.1 mu g/mL. The in vitro DPPH radical scavenging activity of the extract was determined as IC50= 0.4 +/- 0.02 mg/mL whereas the standard BHT IC50 was 0.01 +/- 0.00 mg/mL. Trolox Equivalent Antioxidant Capacity (TEAC) of extract was determined 1.3 mM TEAC, while BHT, 1.9 mM TEAC.

引用

页码：639 / 644

页数：6

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