Activation of a C(sp3)?H Bond by a Transient s-Alkylpalladium(II) Complex: Synthesis of Spirooxindoles Through a Palladium-Catalyzed Domino Carbopalladation/C(sp3)?C(sp3) Bond-Forming Process

被引：172
|
作者：
Piou, Tiffany [2 ]
Neuville, Luc [1 ]
Zhu, Jieping [2 ]
机构：
[1] CNRS, Inst Chim Subst Nat, Lab Int Associe, Ctr Rech Gif, F-91198 Gif Sur Yvette, France
[2] Ecole Polytech Fed Lausanne, EPFL SB ISIC LSPN, BCH 5304, CH-1015 Lausanne, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 46期
基金：
瑞士国家科学基金会;
关键词：
C-H activation; domino reaction; heterocycles; palladium; spirooxindoles; C-H ACTIVATION; C(SP(3))-H BONDS; DIRECT ARYLATION; CYCLIZATION; FUNCTIONALIZATION; CONSTRUCTION; INDOLINES; OXINDOLES; ALKENES; CARBON;
D O I：
10.1002/anie.201206267
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Heck shortens the distance: A method for the palladium-catalyzed activation of a C(sp 3)-H bond by a σ-alkyl Pd II complex generated in-situ from a remote arylhalide function has been developed. This approach allows a novel domino carbopalladation/C(sp 3)-C(sp 3) bond-forming process to provide rapid access to biologically relevant spirooxindoles. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11561 / 11565
页数：5
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