A new method for the construction of [1,2,4]triazolo[1,5-a]pyridine system

被引：2
|
作者：
Kovtunenko, Volodymyr A. [1 ]
Potikha, Lyudmila M. [1 ]
Shelepyuk, Andriy V. [2 ]
Tarasiuk, Taras N. [1 ]
机构：
[1] Kyiv Natl Taras Shevchenko Univ, 64 Volodymyrska St, UA-01033 Kiev, Ukraine
[2] Enamine Ltd, 78 Chervonotkatska St, UA-02660 Kiev, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2019年 / 55卷 / 4-5期
关键词：
4-amino-4H-1,2,4-triazole; 1-amino-1H-[1; 2; 4]triazolo[1; 5-a]pyridine; -bromodipnone; 5-(bromomethyl)-2,2,6,6-tetramethylhept-4-en-3-one; deamination; quaternization; ONE-POT SYNTHESIS; RING;
D O I：
10.1007/s10593-019-02466-w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Quaternization of 4-amino-4H-1,2,4-triazole with -bromodipnones and 5-(bromomethyl)-2,2,6,6-tetramethylhept-4-en-3-one occurred at the N-1 nitrogen atom, with the formation of quaternary salts that were cyclized in the presence of bases into [1,2,4]triazolo[1,5-a]-pyridine derivatives. Quaternary 4-amino-4H-1,2,4-triazolium salts and aromatic 1-amino-1H-[1,2,4]triazolo[1,5-a]pyridinium salts can be deaminated by treatment with nitrous acid, giving 1-substituted 1,2,4-triazoles and the respective [1,2,4]triazolo[1,5-a]pyridines.
引用
收藏
页码：367 / 373
页数：7
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