Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin

被引:61
|
作者
Rosato, A
Vicarini, H
Leclercq, R
机构
[1] Univ Caen, Hop Cote Nacre, F-14033 Caen, France
[2] Univ Paris 12, Hop Henri Mondor, Serv Bacteriol Virol, F-94010 Creteil, France
关键词
D O I
10.1093/jac/43.4.559
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Thirty-five of 40 clinical isolates of enterococci and streptococci cross-resistant to erythromycin and lincomycin and harbouring erm genes were inducibly resistant to these drugs, suggesting that ribosomal methylation is predominantly inducibly expressed in these bacterial genera, Regulatory regions located upstream of the erm genes of four inducible and three constitutive strains were amplified and sequenced. Expression of constitutive resistance in two strains of Streptococcus pneumoniae and Enterococcus faecalis could be accounted for by a large deletion or a DNA duplication within the regulatory regions, respectively.
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页码:559 / 562
页数:4
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