Novel non-nucleoside HCV NS5B inhibitors exhibit low potential for CYP-mediated drug-drug interactions

被引：0
|
作者：
Sergeeva, Maria [1 ]
LeBrun, Laurie A. [1 ]
Hou, Huiying [1 ]
Kirkovsky, Leo [1 ]
Zhou, Yuefen [1 ]
机构：
[1] Anadys Pharmaceut Inc, San Diego, CA USA
来源：
FASEB JOURNAL | 2009年 / 23卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
749.6
引用
收藏
页数：1
相关论文
共 50 条
  • [1] The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors
    Membreno, Fernando E.
    Lawitz, Eric J.
    CLINICS IN LIVER DISEASE, 2011, 15 (03) : 611 - +
  • [2] HCV Non-Nucleoside NS5B Polymerase Inhibitors
    Wu Daochun
    He Yanping
    PROGRESS IN CHEMISTRY, 2012, 24 (11) : 2255 - 2267
  • [3] Discovery of a novel lactam-containing non-nucleoside class of HCV NS5B inhibitors
    Li, Pan
    Green, Jeremy
    Lauffer, David
    Tang, Qing
    Chan, Laval
    Poisson, Carl
    Court, John
    Waal, Nathan
    Ronkin, Steve
    Nanthakumar, Suganthi
    Das, Sanjoy Kumar
    Yannopoulos, Constantin
    Dorsch, Warren
    Mani, Nagraj
    Bilimoria, Darius
    Shawgo, Rebecca
    Rao, Govinda
    Nicolas, Olivier
    Chauret, Nathalie
    Selliah, Subajini
    Denis, Francois
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [4] Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
    Stammers, Timothy A.
    Coulombe, Rene
    Rancourt, Jean
    Thavonekham, Bounkham
    Fazal, Gulrez
    Goulet, Sylvie
    Jakalian, Araz
    Wernic, Dominic
    Tsantrizos, Youla
    Poupart, Marc-Andre
    Boes, Michael
    McKercher, Ginette
    Thauvette, Louise
    Kukolj, George
    Beaulieu, Pierre L.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (09) : 2585 - 2589
  • [5] MEDI 268-Allosteric non-nucleoside inhibitors of HCV RNA polymerase (NS5B)
    Burns, Christopher J.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [6] Discovery of novel potent HCV NS5B polymerase non-nucleoside inhibitors bearing a fused benzofuran scaffold
    Zhong, Min
    Peng, Eric
    Huang, Ningwu
    Huang, Qi
    Huq, Anja
    Lau, Meiyen
    Colonno, Richard
    Li, Leping
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (05) : 963 - 968
  • [7] IN VITRO AND IN VIVO POTENTIAL OF ZURANOLONE TO CAUSE CYP-MEDIATED DRUG-DRUG INTERACTIONS.
    Dunbar, J.
    Srinivas, N.
    Hoffmann, E.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2023, 113 : S36 - S36
  • [8] PRECLINICAL CHARACTERIZATION OF NOVEL POTENT NON-NUCLEOSIDE NS5B PALM SITE INHIBITORS
    Thompson, P. A.
    Tran, C. V.
    Murphy, D. E.
    Xiang, A. X.
    Patel, R. A.
    Hou, H.
    Showalter, R. E.
    Liao, X.
    Appleman, J. R.
    Webber, S. E.
    JOURNAL OF HEPATOLOGY, 2011, 54 : S491 - S491
  • [9] Non-nucleoside Inhibitors of NS5B Polymerase from HCV, Genotypes 1b and 2a
    James, Michael
    Biswal, Bichitra
    Wang, Meitian
    Cherney, Maia
    Chan, Laval
    Yannopoulos, Constantin
    Bilimoria, Darius
    Nicolas, Olivier
    Bedard, Jean
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2005, 61 : C50 - C50
  • [10] Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B
    Schoenfeld, Ryan C.
    Bourdet, David L.
    Brameld, Ken A.
    Chin, Elbert
    de Vicente, Javier
    Fung, Amy
    Harris, Seth F.
    Lee, Eun K.
    Le Pogam, Sophie
    Leveque, Vincent
    Li, Jim
    Lui, Alfred S. -T.
    Najera, Isabel
    Rajyaguru, Sonal
    Sangi, Michael
    Steiner, Sandra
    Talamas, Francisco X.
    Taygerly, Joshua P.
    Zhao, Junping
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (20) : 8163 - 8182
12345