Transition-metal-free synthesis of quinolines from 2-nitrobenzyl alcohol in water

被引：15
|
作者：
Zhu, Meijuan [1 ,2 ]
Wang, Chao [1 ,2 ]
Tang, Weijun [1 ,2 ]
Xiao, Jianliang [1 ,2 ,3 ]
机构：
[1] Shaanxi Normal Univ, Key Lab Appl Surface & Colloid Chem, Minist Educ, Xian 710062, Peoples R China
[2] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710062, Peoples R China
[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 48期
基金：
英国工程与自然科学研究理事会; 中国国家自然科学基金;
关键词：
Quinolines; 2-Nitrobenzyl alcohol; Ketones; Aqueous reaction; Base; TRANSFER HYDROGENATION; REDUCTIVE AMINATION; ELECTRON; CATALYST; 1,10-PHENANTHROLINE; CYCLIZATION; ACTIVATION; COMPLEXES; BUTOXIDE; SOLVENT;
D O I：
10.1016/j.tetlet.2015.10.062
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the synthesis of quinolines from cheap and readily available 2-nitrobenzyl alcohol without a transition-metal catalyst in water has been developed, providing a convenient method for accessing quinolines. The reaction features an intramolecular redox process, which generates the key intermediate leading to product formation. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6758 / 6761
页数：4
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