Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles

被引：35
|
作者：
Zheng, Linfeng [1 ]
Zhu, Jingyi [2 ]
Shen, Mingwu [3 ]
Chen, Xisui [4 ]
Baker, James R., Jr. [4 ]
Wang, Su He [4 ]
Zhang, Guixiang [1 ]
Shi, Xiangyang [2 ,3 ,5 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Affiliated Peoples Hosp 1, Dept Radiol, Shanghai 200080, Peoples R China
[2] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China
[3] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
[4] Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA
[5] Univ Madeira, CQM Ctr Quim Madeira, P-9000390 Funchal, Portugal
来源：
MEDCHEMCOMM | 2013年 / 4卷 / 06期
基金：
中国国家自然科学基金;
关键词：
DELIVERY; ACID; ACETYLATION;
D O I：
10.1039/c3md00050h
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Generation 5-poly(amidoamine) dendrimers pre-modified with folic acid and methotrexate (G5-FA-MTX) were used as templates for the synthesis of dendrimer-entrapped gold nanoparticles (Au DENPs). The synthesized [(Au-0)(50)-G5-FA-MTX] DENPs were able to target and specifically inhibit the growth of cancer cells overexpressing high affinity folic acid receptors.
引用
收藏
页码：1001 / 1005
页数：5
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