Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

被引：19
|
作者：
Khalid, Asma [1 ]
Lodin, Rebecca [2 ]
Domachuk, Peter [2 ]
Tao, Hu [3 ]
Moreau, Jodie E. [3 ]
Kaplan, David L. [3 ]
Omenetto, Fiorenzo G. [3 ,4 ]
Gibson, Brant C. [1 ]
Tomljenovic-Hanic, Snjezana [1 ]
机构：
[1] Univ Melbourne, Sch Phys, Parkville, Vic 3010, Australia
[2] Univ Sydney, Sch Phys, Camperdown, NSW 2006, Australia
[3] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA
[4] Tufts Univ, Dept Phys, Medford, MA 02155 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 02期
基金：
澳大利亚研究理事会;
关键词：
ELECTRIC-DIPOLES; CYTOTOXICITY; DIAMOND;
D O I：
10.1364/BOE.5.000596
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A new hybrid material consisting of nanodiamonds (NDs) and silk has been synthesized and investigated. NDs can contain bright fluorescence centers, important for bioprobes to image biological structures at the nanoscale and silk provides a transparent, robust matrix for these nanoparticles in-vivo or in-vitro. The ND-silk hybrid films were determined to be highly transparent in the visible to near infrared wavelength range. The NDs embedded in silk exhibited significant enhancement of emission relative to air, correlating with theoretical predictions. Furthermore, animal toxicity tests confirmed ND-silk films to be non-toxic in an in-vivo mice model. (C) 2014 Optical Society of America
引用
收藏
页码：596 / 608
页数：13
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