Enantiomeric resolution on L-carnitine selective polymers prepared by molecular imprinting

被引：0
|
作者：
Li, XT
Jiang, GG
Shi, YH
Xu, ZD
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
[2] Zhejiang Univ, Dept Chem Engn, Hangzhou 310027, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2002年 / 13卷 / 02期
关键词：
L-carnitine; racemic carnitine hydrochloride; molecular imprinting polymer; HPLC;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
L-carnitine selective polymers were prepared by molecular imprinting using methacrylic acid as the functional monomer. The acid function of the monomer is expected to form hydrogen bond and ionic interactions with the amine function of the target molecule L-carnitine. The imprinted polymers were used as stationary phases in high-performance liquid chromatography (HPLC). It was shown that L-carnitine imprinted polymer exhibited a higher affinity to its template molecule, while the non-imprinted polymer had no affinity to the compounds tested. Racemic carnitine hydrochloride was efficiently resolved on the L-carnitine imprinted polymer, and the separation factor is 1.9.
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页码：157 / 158
页数：2
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