Organocatalytic Asymmetric Michael Addition of Ketones toα,β-Unsaturated Nitro Compounds

被引：11
|
作者：
Shim, Jae Ho [1 ]
Nam, Si Hun [1 ]
Kim, Byeong-Seon [2 ,3 ]
Ha, Deok-Chan [1 ]
机构：
[1] Korea Univ, Res Inst Nat Sci, Dept Chem, 145 Anam Ro, Seoul 02841, South Korea
[2] Gyeongsang Natl Univ, Dept Chem Educ, Jinju 52828, South Korea
[3] Gyeongsang Natl Univ, Res Inst Nat Sci, Jinju 52828, South Korea
来源：
CATALYSTS | 2020年 / 10卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
organocatalyst; enantioselectivity; yield; thiourea catalyst; asymmetric; CONJUGATE ADDITION; AROMATIC KETONES; CATALYSTS; ENANTIOMERS; AMINES; DONORS;
D O I：
10.3390/catal10060618
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An organic catalyst "(R,R)-1,2-diphenylethylenediamine(DPEN) derivative'' was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones totrans-beta-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee).
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页数：11
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