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Sorbonne Univ, Pitie Salpetriere Hosp, AP HP,CIC 1901,UMR S 1166, Dept Pharmacol,Pharmacokinet & Therapeut Drug Mon, F-75013 Paris, France Sorbonne Univ, Pitie Salpetriere Hosp, AP HP,CIC 1901,UMR S 1166, Dept Pharmacol,Pharmacokinet & Therapeut Drug Mon, F-75013 Paris, France