Total Synthesis of (+)-Clavilactone A and (-)-Clavilactone B by Ring-Opening/Ring-Closing Metathesis

被引：45

作者：

Takao, Ken-ichi ^{[1
]}

Nanamiya, Ryuki ^{[1
]}

Fukushima, Yuuki ^{[1
]}

Namba, Ayumi ^{[1
]}

Yoshida, Keisuke ^{[1
]}

Tadano, Kin-ichi ^{[1
]}

机构：

[1] Keio Univ, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 21期

关键词：

REARRANGEMENT METATHESIS; STRUCTURE ELUCIDATION; MOSHER METHOD; ALDEHYDES; CLAVILACTONES; FACILE; BINOL; DIOLS; ACID;

D O I：

10.1021/ol4027842

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective total synthesis of natural enantiomers of clavilactones A and B has been achieved. A key feature of the synthesis is the use of a ring-opening/ring-closing metathesis, which allows the one-pot transformation of a strained cyclobutenecarboxylate into a gamma-butenolide.

引用

页码：5582 / 5585

页数：4

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