The Splenic Microenvironment Is a Novel Site of Relapse Following ABT-199 Treatment

被引：0
|
作者：
Di Grande, Alessandra [1 ]
Piers, Sofie [2 ]
Van Vlierberghe, Pieter [2 ]
Chonghaile, Triona Ni [1 ]
机构：
[1] Royal Coll Surgeons Ireland, Physiol & Med Phys, Dublin, Ireland
[2] Univ Ghent, Dept Biomol Med, Ghent, Belgium
来源：
BLOOD | 2019年 / 134卷
关键词：
D O I：
10.1182/blood-2019-127970
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
3800
引用
收藏
页数：2
相关论文
共 43 条
  • [1] ABT-199 and epigenetic modifiers: promising novel combinations for the treatment of Multiple Myeloma
    Flanagan, Lyndsey
    Chonghaile, Triona Ni
    Glavey, Siobhan
    O'Dwyer, Michael
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S90 - S90
  • [2] The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL
    Di Grande, Alessandra
    Peirs, Sofie
    Donovan, Paul D.
    Van Trimpont, Maaike
    Morscio, Julie
    Lintermans, Beatrice
    Reunes, Lindy
    Vandamme, Niels
    Goossens, Steven
    Hien Anh Nguyen
    Lavie, Arnon
    Lock, Richard B.
    Prehn, Jochen H. M.
    Van Vlierberghe, Pieter
    Chonghaile, Triona Ni
    BLOOD ADVANCES, 2021, 5 (07) : 1963 - 1976
  • [3] Idelalisib Interferes with the Crosstalk of Follicular Lymphoma and Its Immune Microenvironment and Potentiates the Activity of ABT-199
    Guerrero-Hernandez, Martina
    Matas-Cespedes, Alba
    Serrat, Neus
    Yahiaoui, Anella
    Valero, Juan G.
    Magnano, Laura
    Rivas-Delgado, Alfredo
    Colomer, Dolors
    Campo, Elias
    Lopez-Guillermo, Armando
    Roue, Gael
    Tannheimer, Stacey
    Perez-Galan, Patricia
    BLOOD, 2017, 130
  • [4] Identification of JNK1 as a predicting biomarker for ABT-199 and paclitaxel combination treatment
    Song, Ting
    Zhang, Minhang
    Liu, Peng
    Xue, Zhenyu
    Fan, Yudan
    Zhang, Zhichao
    BIOCHEMICAL PHARMACOLOGY, 2018, 155 : 102 - 109
  • [5] Doxorubicin and ABT-199 Coencapsulated Nanocarriers for Targeted Delivery and Synergistic Treatment against Hepatocellular Carcinoma
    Zhou, Yun
    Li, Ke
    Li, Fan
    Han, Shuang
    Wang, Yang
    Li, Xueping
    Zhan, Yonghua
    JOURNAL OF NANOMATERIALS, 2019, 2019
  • [6] A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies
    Phillips, Darren C.
    Jin, Sha
    Gregory, Gareth P.
    Zhang, Qi
    Xue, John
    Zhao, Xiaoxian
    Chen, Jun
    Tong, Yunsong
    Zhang, Haichao
    Smith, Morey
    Tahir, Stephen K.
    Clark, Rick F.
    Penning, Thomas D.
    Devlin, Jennifer R.
    Shortt, Jake
    Hsi, Eric D.
    Albert, Daniel H.
    Konopleva, Marina
    Johnstone, Ricky W.
    Leverson, Joel D.
    Souers, Andrew J.
    LEUKEMIA, 2020, 34 (06) : 1646 - 1657
  • [7] A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies
    Darren C. Phillips
    Sha Jin
    Gareth P. Gregory
    Qi Zhang
    John Xue
    Xiaoxian Zhao
    Jun Chen
    Yunsong Tong
    Haichao Zhang
    Morey Smith
    Stephen K. Tahir
    Rick F. Clark
    Thomas D. Penning
    Jennifer R. Devlin
    Jake Shortt
    Eric D. Hsi
    Daniel H. Albert
    Marina Konopleva
    Ricky W. Johnstone
    Joel D. Leverson
    Andrew J. Souers
    Leukemia, 2020, 34 : 1646 - 1657
  • [8] Susceptibility of CLL cells to ABT-199 treatment is increased by neutralization of BAFF (B cell activating factor) with Belimumab
    Tandler, C.
    Schmidt, M.
    Schmidt, J.
    Wild, J.
    Strunz, B.
    Doerfel, D.
    Kanz, L.
    Salih, H. R.
    ONCOLOGY RESEARCH AND TREATMENT, 2017, 40 : 141 - +
  • [9] Combined Targeting of Mcl-1 With TG02 and Bcl-2 With ABT-199/ABT-737 for Treatment of Hematologic Malignancies
    Burrows, Francis
    Yu, Ning
    Abdul-Aziz, Amina
    Hitosugi, Sadae
    Seedhouse, Claire
    Russell, Nigel
    Boise, Lawrence H.
    Pallis, Monica
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2014, 14 : S152 - S152
  • [10] Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199)
    Patel, V. M.
    Balakrishnan, K.
    Douglas, M.
    Tibbitts, T.
    Xu, E. Y.
    Kutok, J. L.
    Ayers, M.
    Sarkar, A.
    Guerrieri, R.
    Wierda, W. G.
    O'Brien, S.
    Jain, N.
    Stern, H. M.
    Gandhi, V.
    LEUKEMIA, 2017, 31 (09) : 1872 - 1881
12345