Body temperature and locomotor activity as marker rhythms of aging of the circadian system in rodents

被引:29
|
作者
Mailloux, A [1 ]
Benstaali, C [1 ]
Bogdan, A [1 ]
Auzéby, A [1 ]
Touitou, Y [1 ]
机构
[1] Univ Paris 06, Serv Biochim Med, F-75634 Paris 13, France
关键词
aging; body temperature; locomotor activity; rhythms desynchronisation; biological clock; rodents;
D O I
10.1016/S0531-5565(99)00051-0
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Most biological functions present rhythmic variations. These rhythms are distinguished by their period and concern all the levels of biological life. Circadian rhythms follow a periodicity close to 24-h, they allow individuals to survive via adaptation to the periodic variations of environment. Throughout the aging process, modifications in circadian rhythms of endocrinological, metabolical and behavioural fields have been found in many animal species. This review updates the body of knowledge on aging-related alterations of the circadian rhythms of body temperature and locomotor activity: modifications in circadian profiles, modifications in the period of free-running rhythms, internal desynchronisations and modifications in entrainment ability of these rhythms. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:733 / 740
页数:8
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