Towards New Uses of Botulinum Toxin as a Novel Therapeutic Tool

被引:26
|
作者
Pickett, Andy [1 ]
Perrow, Karen [1 ]
机构
[1] Ipsen Biopharm Ltd, Wrexham LL13 9UF, Wales
来源
TOXINS | 2011年 / 3卷 / 01期
关键词
clostridial neurotoxin; BoNT; engineering; targeting; NEUROTOXIN TYPE-A; H-C FRAGMENT; RELEASE IN-VITRO; CLOSTRIDIUM-BOTULINUM; SEROTYPE-A; TETANUS TOXIN; LIGHT-CHAIN; SUBSTRATE RECOGNITION; GENE DELIVERY; BINDING-SITE;
D O I
10.3390/toxins3010063
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The uses of botulinum toxin in the fields of neurology, ophthalmology, urology, rehabilitation medicine and aesthetic applications have been revolutionary for the treatment of patients. This non-invasive therapeutic has continually been developed since first discovered in the 1970s as a new approach to what were previously surgical treatments. As these applications develop, so also the molecules are developing into tools with new therapeutic properties in specific clinical areas. This review examines how the botulinum toxin molecule is being adapted to new therapeutic uses and also how new areas of use for the existing molecules are being identified. Prospects for future developments are also considered.
引用
收藏
页码:63 / 81
页数:19
相关论文
共 50 条
  • [1] THERAPEUTIC USES OF BOTULINUM TOXIN
    JANKOVIC, J
    BRIN, MF
    NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17): : 1186 - 1194
  • [2] Therapeutic uses of botulinum toxin
    Wheeler, AH
    AMERICAN FAMILY PHYSICIAN, 1997, 55 (02) : 541 - 545
  • [3] Therapeutic uses of Clostridium botulinum toxin.
    Ranoux, D
    Mas, JL
    SEMAINE DES HOPITAUX, 1997, 73 (23-24): : 766 - 772
  • [4] The development of botulinum toxin as a therapeutic tool
    Riley, D. E.
    Magoon, E. H.
    MOVEMENT DISORDERS, 2013, 28 : S412 - S413
  • [5] Uses of botulinum toxin
    Girdler, NM
    LANCET, 1997, 349 (9056): : 953 - 953
  • [6] Novel Cosmetic Uses of Botulinum Toxin in the Head and Neck
    Isabel Fairmont
    Andrew Winkler
    Current Otorhinolaryngology Reports, 2020, 8 : 344 - 350
  • [7] Novel Cosmetic Uses of Botulinum Toxin in the Head and Neck
    Fairmont, Isabel
    Winkler, Andrew
    CURRENT OTORHINOLARYNGOLOGY REPORTS, 2020, 8 (04) : 344 - 350
  • [8] A novel therapeutic approach in tetanus: Botulinum toxin
    Demir, N. Aktug
    Ozturk, S.
    Sumer, S.
    Ural, O.
    Celik, J. B.
    Ozcimen, S.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2014, 21 : 202 - 202
  • [9] Therapeutic Uses and Efficacy of Botulinum Toxin in Orofacial Medicine: A Dental Perspective
    Yoshida, Kazuya
    Bakke, Merete
    TOXINS, 2024, 16 (05)
  • [10] Therapeutic uses of botulinum toxin: from facial palsy to autonomic disorders
    de Maio, Mauricio
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2008, 8 (06) : 791 - 798