THE ROLE OF LEPTIN IN PATHOGENESIS OF OBESITY-RELATED CANCERS

被引：0
|
作者：
Nowak, Aleksandra [1 ]
Kobierzycki, Christopher [1 ]
Dziegiel, Piotr [1 ]
机构：
[1] Uniwersytet Med Wroclawiu, Katedra & Zaklad Histol & Embriol, Wroclaw, Poland
来源：
POSTEPY BIOLOGII KOMORKI | 2015年 / 42卷 / 02期
关键词：
leptin; obesity; cancerogenesis; EPITHELIAL-MESENCHYMAL TRANSITION; MESSENGER-RNA EXPRESSION; BODY-MASS INDEX; BREAST-CANCER; CELL-PROLIFERATION; PROSTATE-CANCER; ENDOMETRIAL CANCER; COLORECTAL-CANCER; SERUM LEPTIN; EPIDEMIOLOGIC EVIDENCE;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Leptin is an adipokine, produced by white adipose tissue, exerting pleiotropic effect. Its main function is regulation of body weight and energy balance via its receptor located in the hypothalamus. Serum leptin concentration significantly correlates with total fat mass and is substantially elevated in obese individuals. In this review, we highlight the role of leptin in pathogenesis of cancers which incidence and prognosis are strongly associated with obesity: breast and endometrial cancer among women, prostate cancer among men and colorectal cancer among both men and women. Additionally, in our review we highlight important impact of leptin on regulation and initiation of angiogenesis and epithelial mesenchymal transition, processes that are highly associated with cancer progression.
引用
收藏
页码：309 / 328
页数：20
相关论文
共 50 条
  • [1] Leptin: A Heavyweight Player in Obesity-Related Cancers
    Caruso, Amanda
    Gelsomino, Luca
    Panza, Salvatore
    Accattatis, Felice Maria
    Naimo, Giuseppina Daniela
    Barone, Ines
    Giordano, Cinzia
    Catalano, Stefania
    Ando, Sebastiano
    BIOMOLECULES, 2023, 13 (07)
  • [2] Role of leptin in obesity-related hypertension
    Aizawa-Abe, M
    Ogawa, Y
    Masuzaki, H
    Ebihara, K
    Shintani, M
    Miyanaga, F
    Nakao, K
    JOURNAL OF HYPERTENSION, 2000, 18 : S120 - S120
  • [3] Role of leptin in obesity-related hypertension
    Haynes, WG
    EXPERIMENTAL PHYSIOLOGY, 2005, 90 (05) : 683 - 688
  • [4] Obesity-Related Colorectal Cancer: The Role of Leptin
    Kim, Hyeong Rok
    ANNALS OF COLOPROCTOLOGY, 2015, 31 (06) : 209 - 210
  • [5] Pathophysiological role of leptin in obesity-related hypertension
    Aizawa-Abe, M
    Ogawa, Y
    Masuzaki, H
    Ebihara, K
    Satoh, N
    Iwai, H
    Matsuoka, N
    Hayashi, T
    Hosoda, K
    Inoue, G
    Yoshimasa, Y
    Nakao, K
    JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (09): : 1243 - 1252
  • [6] Obesity-related hypertension: Is there a role for selective leptin resistance?
    Correia, MLG
    Haynes, WG
    CURRENT HYPERTENSION REPORTS, 2004, 6 (03) : 230 - 235
  • [7] Obesity-related hypertension: Is there a role for selective leptin resistance?
    Marcelo L. G. Correia
    William G. Haynes
    Current Hypertension Reports, 2004, 6 : 230 - 235
  • [8] Symposium 3: Obesity-related cancers Molecular mechanisms linking adipokines to obesity-related colon cancer: focus on leptin
    Drew, Janice E.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2012, 71 (01) : 175 - 180
  • [9] Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
    Bouter, Kristien E.
    van Raalte, Daniel H.
    Groen, Albert K.
    Nieuwdorp, Max
    GASTROENTEROLOGY, 2017, 152 (07) : 1671 - 1678
  • [10] Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer
    Marques, Vanda
    Arella, Fabiola
    Afonso, Marta B.
    Santos, Andre A.
    Rodrigues, Cecilia M. P.
    CLINICAL SCIENCE, 2023, 137 (15) : 1095 - 1114
12345