A Malignant Cutaneous Neuroendocrine Tumor With Features of Merkel Cell Carcinoma and Differentiating Neuroblastoma

被引：11
|
作者：
Vanchinathan, Vijay [1 ]
Marinelli, Elena C. [1 ]
Kartha, Reena V. [1 ]
Uzieblo, Alison [1 ,2 ]
Ranchod, Mahendra [3 ]
Sundram, Uma N. [1 ,4 ]
机构：
[1] Stanford Univ, Dept Pathol, Med Ctr, Stanford, CA 94305 USA
[2] William Beaumont Hosp, Dept Pathol, Royal Oak, MI 48072 USA
[3] Good Samaritan Hosp, Dept Pathol, San Jose, CA USA
[4] Stanford Univ, Dept Dermatol, Sch Med, Stanford, CA 94305 USA
来源：
AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2009年 / 31卷 / 02期
关键词：
Merkel cell carcinoma; neuroblastoma; cutaneous; CK-20; primitive neuroectodermal tumor; GANGLIONEUROBLASTIC DIFFERENTIATION; SKIN; EXPRESSION; ECCRINE; LUNG;
D O I：
10.1097/DAD.0b013e31819114c4
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report an unusual primary cutaneous neuroendocrine carcinoma that shows histologic and immunohistochemical features of ganglioneuroblastoma/differentiating neuroblastoma. The neoplasm is composed predominantly of small atypical neoplastic cells embedded in distinct clusters of immature and mature ganglion cells with associated neuropil. The neoplastic cells show strong perinuclear staining for cytokeratin 20 (CK20) with a dot-like pattern, supporting our contention that this is an unusual variant of Merkel cell carcinoma. To the best of our knowledge, ganglioneuroblastoma-like differentiation has not been previously described in Merkel cell carcinoma.
引用
收藏
页码：193 / 196
页数：4
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