EVALUATION OF ACUTE ORAL TOXICITY OF BUTTERFLY PEA ROOT EXTRACT ON EXPERIMENTAL MICE

Clitoria ternatea (CT), is an herbaceous medicinal plant used to treat brain related disorders and dementia. The purpose of this study was to test the acute oral toxicity of the extracts of roots plant. Acute toxicity of Butterfly Pea Roots extract was evaluated in DDY-mice. The acute toxicity studies were adopted from OECD guidelines 423 and Lu (1995). The animals were orally administered a single dose of 2500, 5000, 10000 and 15000 mg/kg body weight. Signs of toxicity and mortality were noted after 1, 4 and 24h of administration of the extract for 14 days. The highest dose administered (15000mg/kg body weight) produced the highest mortality rate and the LD50 of Butterfly Pea roots extract is 32118.533 mg/kg based on Probit Analysis. The histopathology studies indicate hepatotoxicity and nephrotoxicity as the acute toxic effect of Butterfly Pea root extract.