Rapid progress in the identification and characterization of axon guidance molecules and their receptors has left the field poised to explore the intracellular mechanisms by which signals are transduced into growth cone responses. The TUC (TOAD/Ulip/CRMP) family of proteins has emerged as a strong candidate for a role in growth cone signaling. The TUC family members reach their highest expression levels in all neurons during their peak periods of axonal growth and are strongly down-regulated afterward. When axonal regrowth in the adult is triggered bg axotomy, TUC-4 is reexpressed during the period of regrowth. Mutations in unc-33, a homologous nematode gene, lead to severe axon guidance errors in all neurons. Furthermore, the TUC family is required for the growth cone-collapsing activity of collapsin-1. An important role for the TUC family is also suggested by its high degree of interspecies amino acid sequence identity, with the rat TUC-2 protein showing 98% identity with its chick ortholog and 89% identity with its Xenopus ortholog. Information gained from the study of the TUC family sill be of key importance in understanding here growth cones find their targets. (C) 1999 John Wiley & Sons, Inc.
机构:
Univ Wisconsin, Dept Anat, Madison, WI 53706 USAMIT, Koch Inst Integrat Canc Res MIT, Cambridge, MA 02139 USA
Dent, Erik W.
Gupton, Stephanie L.
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MIT, Koch Inst Integrat Canc Res MIT, Cambridge, MA 02139 USA
Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USAMIT, Koch Inst Integrat Canc Res MIT, Cambridge, MA 02139 USA
Gupton, Stephanie L.
Gertler, Frank B.
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MIT, Koch Inst Integrat Canc Res MIT, Cambridge, MA 02139 USAMIT, Koch Inst Integrat Canc Res MIT, Cambridge, MA 02139 USA
Gertler, Frank B.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY,
2011,
3
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: 1
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39
机构:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pathol, Piscataway, NJ 08854 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pathol, Piscataway, NJ 08854 USA
Quinn, Christopher C.
Wadsworth, William G.
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Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pathol, Piscataway, NJ 08854 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pathol, Piscataway, NJ 08854 USA
机构:
Columbia Univ, Naomi Berrie Diabet Ctr, New York, NY 10027 USA
Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10027 USAColumbia Univ, Naomi Berrie Diabet Ctr, New York, NY 10027 USA