Exploring high affinity inhibitors of M-tuberculosis thymidiylate kinase

被引：0
|
作者：
Van Daele, I [1 ]
Munier-Lehmann, H [1 ]
Van Calenbergh, S [1 ]
机构：
[1] State Univ Ghent, FFW, Lab Med Chem, B-9000 Ghent, Belgium
来源：
Chemistry of Nucleic Acid Components | 2005年 / 7卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of new bicyclic (5-9) and thiourea (10-14) thymidine derivatives have been synthezised as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that previously synthezised 2 and thioureum derivative 14 are the most favourable leads for further development of potent inhibitors of this enzyme.
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页码：313 / 314
页数：2
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