Efficient synthesis of dihydropyrido[4,3-d]pyrimidines by microwave-promoted three-component aza-Diels-Alder reaction

被引：18
|
作者：
Sarmah, Manas M. [1 ]
Sarma, Rupam [1 ,2 ]
Prajapati, Dipak [1 ]
Hu, Wenhao [3 ]
机构：
[1] CSIR NE Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India
[2] Nalbari Coll, Dept Chem, Nalbari 781335, Assam, India
[3] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 03期
关键词：
Aza-Diels-Alder reaction (ADA); Pyrido[4,3-d]pyrimidine; Multi-component reaction (MCR); Green chemistry; TYROSINE KINASE INHIBITORS; ONE-POT SYNTHESIS; KETONES; CYCLIZATION; PYRIMIDINE; CATALYST;
D O I：
10.1016/j.tetlet.2012.11.018
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A microwave-promoted solvent- and catalyst-free aza-Diels-Alder reaction is described. 6-[2-(dimethylamino)vinyl]-1,3-dimethyluracil reacts with aldehyde and amine inside a microwave reactor to produce dihydropyrido[4,3-d]pyrimidine derivatives in excellent yield and within a yew short time. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：267 / 271
页数：5
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