Lack of association of type 1 diabetes with the IL4R gene

被引：2
|
作者：
Qu, HQ
Tessier, MC
Fréchette, R
Bacot, F
Polychronakos, C
机构：
[1] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Dept Pediat, Montreal, PQ H3H 1P3, Canada
[2] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Endocrine Genet Lab, Montreal, PQ H3H 1P3, Canada
来源：
DIABETOLOGIA | 2006年 / 49卷 / 05期
关键词：
interleukin; 4; receptor; population stratification; transmission disequilibrium test; Type; 1; diabetes;
D O I：
10.1007/s00125-006-0199-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The association between IL4R and type 1 diabetes has been tested in many studies in recent years, with contradictory results. The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background. We genotyped six non-synonymous single-nucleotide polymorphisms (SNPs) of the IL4R gene in 830 nuclear families as specified above, including a French Canadian subset. No association between type 1 diabetes and any SNP or haplotype was found by the transmission disequilibrium test. Previous positive reports may be due to population stratification as, according to HapMap data, allele frequencies in the IL4R region vary considerably by ethnicity.
引用
收藏
页码：958 / 961
页数：4
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