Machine learning-based predictive and risk analysis using real-world data with blood biomarkers for hepatitis B patients in the malignant progression of hepatocellular carcinoma
被引:5
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作者:
Nan, Yuemin
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Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R ChinaHebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R China
Nan, Yuemin
[1
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Zhao, Suxian
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Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R ChinaHebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R China
Zhao, Suxian
[1
]
Zhang, Xiaoxiao
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Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R ChinaHebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R China
Zhang, Xiaoxiao
[1
]
Xiao, Zhifeng
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机构:
Behrend Coll, Sch Engn, Penn State Erie, Erie, PA USAHebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R China
Xiao, Zhifeng
[2
]
Guo, Ruihan
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Shanghai Ashermed Healthcare Co Ltd, Shanghai, Peoples R ChinaHebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R China
Guo, Ruihan
[3
]
机构:
[1] Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Hebei Prov Key Lab Liver Fibrosis Chron Liver Dis, Shijiazhuang, Peoples R China
[2] Behrend Coll, Sch Engn, Penn State Erie, Erie, PA USA
[3] Shanghai Ashermed Healthcare Co Ltd, Shanghai, Peoples R China
Hepatitis B Virus (HBV) infection may lead to various liver diseases such as cirrhosis, end-stage liver complications, and Hepatocellular carcinoma (HCC). Patients with existing cirrhosis or severe fibrosis have an increased chance of developing HCC. Consequently, lifetime observation is currently advised. This study gathered real-world electronic health record (EHR) data from the China Registry of Hepatitis B (CR-HepB) database. A collection of 396 patients with HBV infection at different stages were obtained, including 1) patients with a sustained virological response (SVR), 2) patients with HBV chronic infection and without further development, 3) patients with cirrhosis, and 4) patients with HCC. Each patient has been monitored periodically, yielding multiple visit records, each is described using forty blood biomarkers. These records can be utilized to train predictive models. Specifically, we develop three machine learning (ML)-based models for three learning tasks, including 1) an SVR risk model for HBV patients via a survival analysis model, 2) a risk model to encode the progression from HBV, cirrhosis and HCC using dimension reduction and clustering techniques, and 3) a classifier to detect HCC using the visit records with high accuracy (over 95%). Our study shows the potential of offering a comprehensive understanding of HBV progression via predictive analysis and identifies the most indicative blood biomarkers, which may serve as biomarkers that can be used for immunotherapy.
机构:
Univ Washington, Comparat Hlth Outcomes Policy & Econ CHOICE Inst, 1959 NE Pacific Str,HSB H-375,Box 357630, Seattle, WA 98195 USAUniv Washington, Comparat Hlth Outcomes Policy & Econ CHOICE Inst, 1959 NE Pacific Str,HSB H-375,Box 357630, Seattle, WA 98195 USA
Rodriguez, Patricia J.
Veenstra, David L.
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Univ Washington, Comparat Hlth Outcomes Policy & Econ CHOICE Inst, 1959 NE Pacific Str,HSB H-375,Box 357630, Seattle, WA 98195 USAUniv Washington, Comparat Hlth Outcomes Policy & Econ CHOICE Inst, 1959 NE Pacific Str,HSB H-375,Box 357630, Seattle, WA 98195 USA
Veenstra, David L.
Heagerty, Patrick J.
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机构:
Univ Washington, Dept Biostat, Seattle, WA 98195 USAUniv Washington, Comparat Hlth Outcomes Policy & Econ CHOICE Inst, 1959 NE Pacific Str,HSB H-375,Box 357630, Seattle, WA 98195 USA
Heagerty, Patrick J.
Goss, Christopher H.
论文数: 0引用数: 0
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机构:
Univ Washington, Dept Med, Div Pulm Crit Care & Sleep Med, Seattle, WA 98195 USA
Univ Washington, Dept Pediat, Div Pulmonol, Seattle, WA 98195 USAUniv Washington, Comparat Hlth Outcomes Policy & Econ CHOICE Inst, 1959 NE Pacific Str,HSB H-375,Box 357630, Seattle, WA 98195 USA
Goss, Christopher H.
Ramos, Kathleen J.
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Univ Washington, Dept Med, Div Pulm Crit Care & Sleep Med, Seattle, WA 98195 USAUniv Washington, Comparat Hlth Outcomes Policy & Econ CHOICE Inst, 1959 NE Pacific Str,HSB H-375,Box 357630, Seattle, WA 98195 USA
机构:
Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea
Severance Hosp, Yonsei Liver Ctr, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Lee, Hye Won
Kim, Hwiyoung
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Yonsei Univ, Ctr Clin Imaging Data Sci CCIDS, Dept Biomed Syst Informat, Coll Med, Seoul, South Korea
Yonsei Univ, Coll Comp, Dept Artificial Intelligence, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Kim, Hwiyoung
Park, Taeyun
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Yonsei Univ, Coll Comp, Dept Artificial Intelligence, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Park, Taeyun
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Park, Soo Young
Chon, Young Eun
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CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Bundang, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Chon, Young Eun
Seo, Yeon Seok
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Korea Univ, Coll Med, Dept Internal Med, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Seo, Yeon Seok
Lee, Jae Seung
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Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea
Severance Hosp, Yonsei Liver Ctr, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Lee, Jae Seung
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Park, Jun Yong
Kim, Do Young
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Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea
Severance Hosp, Yonsei Liver Ctr, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Kim, Do Young
Ahn, Sang Hoon
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Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea
Severance Hosp, Yonsei Liver Ctr, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Ahn, Sang Hoon
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Kim, Beom Kyung
Kim, Seung Up
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Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea
Severance Hosp, Yonsei Liver Ctr, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
机构:
Wuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R China
Xiong, Ronghong
Wang, Hui
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Wuhan Univ, Demonstrat Ctr Expt Basic Med Educ, Sch Basic Med Sci, Dept Med Genet, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R China
Wang, Hui
Li, Ying
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Wuhan Univ, Demonstrat Ctr Expt Basic Med Educ, Sch Basic Med Sci, Dept Med Genet, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R China
Li, Ying
Zheng, Jingpeng
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Wuhan Univ, Demonstrat Ctr Expt Basic Med Educ, Sch Basic Med Sci, Dept Med Genet, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R China
Zheng, Jingpeng
Cheng, Yating
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Wuhan Univ, Demonstrat Ctr Expt Basic Med Educ, Sch Basic Med Sci, Dept Med Genet, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R China
Cheng, Yating
Liu, Shunfang
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Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R China
Liu, Shunfang
Yang, Guohua
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Wuhan Univ, Demonstrat Ctr Expt Basic Med Educ, Sch Basic Med Sci, Dept Med Genet, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Clin Coll 2, Wuhan, Peoples R China
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AIT Austrian Inst Technol GmbH, Ctr Digital Safety & Secur, Vienna, AustriaAIT Austrian Inst Technol GmbH, Ctr Digital Safety & Secur, Vienna, Austria
Loeschenbrand, David
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Hofer, Markus
Eller, Lukas
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机构:
TU Wien, Inst Telecommun, Vienna, Austria
TU Wien, Inst Telecommun, Christian Doppler Lab Digital Twin Assisted AI Su, Vienna, AustriaAIT Austrian Inst Technol GmbH, Ctr Digital Safety & Secur, Vienna, Austria
Eller, Lukas
Rupp, Markus
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机构:
TU Wien, Inst Telecommun, Vienna, AustriaAIT Austrian Inst Technol GmbH, Ctr Digital Safety & Secur, Vienna, Austria
Rupp, Markus
Zemen, Thomas
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AIT Austrian Inst Technol GmbH, Ctr Digital Safety & Secur, Vienna, AustriaAIT Austrian Inst Technol GmbH, Ctr Digital Safety & Secur, Vienna, Austria
Zemen, Thomas
FIFTY-SEVENTH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS & COMPUTERS, IEEECONF,
2023,
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987
机构:
Navajo Indian Hlth Serv, Chinle, AZ USANavajo Indian Hlth Serv, Chinle, AZ USA
Orcutt, Xavier
Chen, Kan
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Harvard Univ, Dept Biostat, Boston, MA 02138 USANavajo Indian Hlth Serv, Chinle, AZ USA
Chen, Kan
Mamtani, Ronac
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机构:
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
Penn Ctr Canc Care Innovat, Abramson Canc Ctr, Philadelphia, PA 19104 USANavajo Indian Hlth Serv, Chinle, AZ USA
Mamtani, Ronac
Long, Qi
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机构:
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
Penn Ctr Canc Care Innovat, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USANavajo Indian Hlth Serv, Chinle, AZ USA
Long, Qi
Parikh, Ravi B.
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机构:
Emory Univ, Sch Med, Atlanta, GA 30322 USA
Winship Canc Inst, Atlanta, GA 30322 USANavajo Indian Hlth Serv, Chinle, AZ USA