Electrophilic Trifluoromethylation by Copper-Catalyzed Addition of CF3-Transfer Reagents to Alkenes and Alkynes

被引：252
|
作者：
Janson, Par G. [1 ]
Ghoneim, Ibrahim [1 ]
Ilchenko, Nadia O. [1 ]
Szabo, Kalman J. [1 ]
机构：
[1] Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 11期
基金：
瑞典研究理事会;
关键词：
ALPHA-TRIFLUOROMETHYLATION; TERMINAL ALKENES; CHEMISTRY; FLUORINE; POSITION; ETHERS; ARENES;
D O I：
10.1021/ol3011419
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Regio- and stereoselective Cu-catalyzed addition of the above hypervalent iodine reagent to alkynes and alkenes was achieved. In the presence of Cul, the reaction is suitable to perform trifluoromethyl-benzoyloxylation and trifluoromethyl-halogenation of alkenes and alkynes. Electron-donating substituents accelerate the process, and alkenes react faster than alkynes emphasizing the electrophilic character of the addition reaction.
引用
收藏
页码：2882 / 2885
页数：4
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