Stereoselective Synthesis of the Monomeric Unit of Actin Binding Macrolide Rhizopodin

被引：33

作者：

Pulukuri, Kiran Kumar ^{[1
]}

Chakraborty, Tushar Kanti ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Lucknow 226001, Uttar Pradesh, India

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 11期

关键词：

BETA-ALKOXY ALDEHYDES; STEREOCONTROLLED SYNTHESIS; 1,3-ASYMMETRIC INDUCTION; SELECTIVE DEPROTECTION; SECONDARY ALCOHOLS; ADDITION-REACTIONS; SWINHOLIDE-A; ACID; MYXOBACTERIA; CONVENIENT;

D O I：

10.1021/ol301103d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, scalable, and stereocontrolled synthesis of the entire carbon framework of an actin binding dimeric macrolide rhizopodin has been accomplished in its protected form. The key features of our synthesis include a titanium catalyzed anti acetal aldol reaction, a substrate controlled diastereoslelective prenyl stannylation, a Mukaiyama aldol reaction, an indium mediated diastereoselective propargylation, and an advanced stage Stille coupling reaction.

引用

页码：2858 / 2861

页数：4

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