Current Concepts in the Pathogenesis of Takotsubo Syndrome

被引：20
|
作者：
Williams, Rupert [1 ]
Arri, Satpal [2 ]
Prasad, Abhiram [1 ]
机构：
[1] St Georges Univ London, Cardiovasc & Cell Sci Res Inst, Cranmer Terrace, London SW17 0RE, England
[2] Kings Coll London, St Thomas Hosp, Rayne Inst, Div Cardiovasc, Westminster Bridge Rd, London SE1 7EH, England
来源：
HEART FAILURE CLINICS | 2016年 / 12卷 / 04期
关键词：
Takotsubo syndrome; Apical ballooning syndrome; Catecholamine; Pathophysiology; TAKO-TSUBO CARDIOMYOPATHY; APICAL BALLOONING SYNDROME; LEFT-VENTRICULAR DYSFUNCTION; ACUTE MYOCARDIAL-INFARCTION; STRESS-INDUCED CARDIOMYOPATHY; ST-SEGMENT ELEVATION; EMOTIONAL-STRESS; CORONARY MICROCIRCULATION; INTRAVASCULAR ULTRASOUND; CARDIOVASCULAR-RESPONSES;
D O I：
10.1016/j.hfc.2016.06.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Takotsubo syndrome is typically characterized by acute reversible impairment of apical and mid-left ventricular systolic function. The pathophysiology is complex and remains to be completely understood. A catecholamine surge appears to be a central feature. Patients with prior history of psychiatric disorders have a predisposition. The putative role of a switch in b-adrenoceptor signalling resulting in negative inotropy remains uncertain. Downregulation of noncritical cellular functions may offer some protection in preventing irreversible cellular necrosis. Microvascular function is a common occurrence in these patients.
引用
收藏
页码：473 / +
页数：13
相关论文
共 50 条
  • [1] Current concepts on the pathogenesis of the antiphospholipid syndrome
    Giannakopoulos, Bill
    Passam, Freda
    Rahgozar, Soheila
    Krilis, Steven A.
    BLOOD, 2007, 109 (02) : 422 - 430
  • [2] Pathogenesis of Takotsubo syndrome
    Masarone, Daniele
    Maddaloni, Valeria
    Rubino, Marta
    Fratta, Fiorella
    Cirillo, Annapaola
    Barrile, Ludovica Spinelli
    Pacileo, Roberta
    Fusco, Adelaide
    Coppola, Guido
    Pisacane, Francesca
    Calabro, Paolo
    Calabro, Raffaele
    Bossone, Eduardo
    Russo, Maria Giovanna
    Pacileo, Giuseppe
    CARDIOGENETICS, 2016, 6 (01) : 31 - 36
  • [3] Current concepts of polycystic ovary syndrome pathogenesis
    Rosenfield, Robert L.
    CURRENT OPINION IN PEDIATRICS, 2020, 32 (05) : 698 - 706
  • [4] DIALYSIS DISEQUILIBRIUM SYNDROME - CURRENT CONCEPTS ON PATHOGENESIS AND PREVENTION
    ARIEFF, AI
    KIDNEY INTERNATIONAL, 1994, 45 (03) : 629 - 635
  • [5] Epidemiology, pathogenesis, and management of takotsubo syndrome
    Y-Hassan, Shams
    Tornvall, Per
    CLINICAL AUTONOMIC RESEARCH, 2018, 28 (01) : 53 - 65
  • [6] Epidemiology, pathogenesis, and management of takotsubo syndrome
    Shams Y-Hassan
    Per Tornvall
    Clinical Autonomic Research, 2018, 28 : 53 - 65
  • [7] Pathogenesis of the Takotsubo Syndrome: A Unifying Hypothesis
    Lindsay, Joseph
    Paixao, Andrea
    Chao, Tania
    Pichard, Augusto D.
    AMERICAN JOURNAL OF CARDIOLOGY, 2010, 106 (09): : 1360 - 1363
  • [8] The current evidence of Takotsubo syndrome
    El-Battrawy, Ibrahim
    Borggrefe, Martin
    Akin, Ibrahim
    FUTURE CARDIOLOGY, 2021, 17 (08) : 1293 - 1295
  • [9] Dysfunctional tear syndrome. Current concepts on classification, diagnostics, and pathogenesis
    Jacobi, C
    Dietrich, T
    Cursiefen, C
    Kruse, FE
    OPHTHALMOLOGE, 2006, 103 (01): : 9 - +
  • [10] The Sympathetic Nervous System in the Pathogenesis of Takotsubo Syndrome
    Wittstein, Ilan S.
    HEART FAILURE CLINICS, 2016, 12 (04) : 485 - +
12345