The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage

被引：19
|
作者：
Tommasini, I [1 ]
Guidarelli, A [1 ]
Cerioni, L [1 ]
Cantoni, O [1 ]
机构：
[1] Univ Urbino, Ist Farmacol & Farmacognosia, I-61029 Urbino, PU, Italy
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 316卷 / 04期
关键词：
peroxynitrite; cytosolic phospholipase A(2); arachidonic acid; mitochondrial permeability transition; cell death;
D O I：
10.1016/j.bbrc.2004.02.172
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
U937, THP-1, and J774 cells or human monocytes and macrophages display similar levels of sensitivity to peroxynitrite and exposure to an otherwise non-toxic concentration of the oxidant in the presence of a phospholipase A, inhibitor was invariably associated with the onset of mitochondrial permeability transition (MPT)-dependent toxicity. These events were prevented by exogenous arachidonic acid (AA). In general, the protective concentrations of AA were greater in those cell types releasing more AA. Thus, non-toxic concentrations of peroxynitrite commit cells belonging to the monocyte/macrophage lineage to MPT-dependent toxicity that is however prevented by endogenous AA. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：1191 / 1195
页数：5
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