Solubility of lamotrigine in 2-propanol + water mixtures at T = (293.2 to 313.2) K

被引：11

作者：

Rezaei, Homa ^{[1
]}

Jouyban, Abolghasem ^{[2
,3
,4
]}

Barzegar-Jalali, Mohammad ^{[3
,5
]}

Martinez, Fleming ^{[6
]}

Rahimpour, Elaheh ^{[7
]}

机构：

[1] Tabriz Univ Med Sci, Fac Pharm, Student Res Comm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[4] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz, Iran

[5] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[6] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim,Sede Bogota, Cra 30 45-03, Bogota, DC, Colombia

[7] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2019年 / 278卷

关键词：

Solubility; Lamotrigine; 2-propanol; Binary solvent mixture; Cosolvency models; Solution thermodynamics; Preferential solvation; PLUS WATER MIXTURES; MATHEMATICAL REPRESENTATION; PREFERENTIAL SOLVATION; SOLVENT MIXTURES; ETHANOL; BINARY; GLYCOL; DRUGS; COSOLVENCY; CLONAZEPAM;

D O I：

10.1016/j.molliq.2019.01.082

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The aims of this study were to investigate the solubility behavior of lamotrigine (LTG) in the binary mixed solvents of 2-propanol and water within the temperature range of 293.2-313.2 K and correlate the experimental values by some mathematical models including the van't Hoff equation, Yalkowsky model, Jouyban-Acree model, Jouyban-Acree-van't Hoff model and the modified Wilson model. The density of the saturated solutions of LTG in various solvent compositions and temperatures was also measured and the results were represented mathematically with Jouyban-Acree model. Furthermore, the apparent thermodynamic properties of LTG dissolving, as well as the preferential solvation, in the investigated mixed solvents were calculated and the details were discussed. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：592 / 599

页数：8

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