Human cathelicidin peptide LL37 binds telomeric G-quadruplex

被引：23
|
作者：
Jana, Jagannath [1 ]
Kar, Rajiv Kumar [1 ]
Ghosh, Anirban [1 ]
Biswas, Atanu [2 ]
Ghosh, Surajit [2 ]
Bhunia, Anirban [1 ]
Chatterjee, Subhrangsu [1 ]
机构：
[1] Bose Inst, Dept Biophys, Biomol NMR & Drug Design Lab, Kolkata, India
[2] CSIR Indian Inst Chem Biol, Div Chem, Kolkata, India
来源：
MOLECULAR BIOSYSTEMS | 2013年 / 9卷 / 07期
关键词：
HUMAN ANTIMICROBIAL PEPTIDE; LL-37; DNA;
D O I：
10.1039/c3mb70030e
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stabilization of G-quadruplex inhibits the activity of the enzyme telomerase in cancer cells. We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures.
引用
收藏
页码：1833 / 1836
页数：4
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