FDG-PET/CT imaging for staging and radiotherapy treatment planning of head and neck carcinoma

被引:64
|
作者
Deantonio, Letizia [1 ]
Beldi, Debora [1 ]
Gambaro, Giuseppina [1 ]
Loi, Gianfranco [2 ]
Brambilla, Marco [2 ]
Inglese, Eugenio [1 ]
Krengli, Marco [1 ]
机构
[1] Univ Piemonte Orientale Amedeo Avogadro, Novara, Italy
[2] Hosp Maggiore Carita, Novara, Italy
关键词
D O I
10.1186/1748-717X-3-29
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Positron emission tomography (PET) has a potential improvement for staging and radiation treatment planning of various tumor sites. We analyzed the use of F-18-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) images for staging and target volume delineation of patients with head and neck carcinoma candidates for radiotherapy. Methods: Twenty-two patients candidates for primary radiotherapy, who did not receive any curative surgery, underwent both CT and PET/CT simulation. Gross Tumor Volume (GTV) was contoured on CT (CT-GTV), PET (PET-GTV), and PET/CT images (PET/CT-GTV). The resulting volumes were analyzed and compared. Results: Based on PET/CT, changes in TNM categories and clinical stage occurred in 5/22 cases (22%). The difference between CT-GTV and PET-GTV was not statistically significant (p = 0.2) whereas the difference between the composite volume (PET/CT-GTV) and CT-GTV was statistically significant (p < 0.0001). Conclusion: PET/CT fusion images could have a potential impact on both tumor staging and treatment planning.
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页数:6
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