Studies on the reaction between ketorolac, feprazone and serum albumin

被引：0

作者：

He, JX ^{[1
]}

Jiang, CQ ^{[1
]}

Wang, HJ ^{[1
]}

Wang, JZ ^{[1
]}

机构：

[1] Shandong Normal Univ, Dept Chem, Jinan 250014, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 1999年 / 20卷 / 10期

关键词：

ketorolac; feprazone; BSA; HSA; fluorescence quenching method;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In paper, by applying fluorescence quenching method and energy transfer technique, the interaction of serum albumin(BSA and HSA) with ketorolac and feprazone was investigated. The binding sites and binding constants were obtained. According to the thermodynamic parameters, the main sorts of binding force can be known. The results show that two drugs and protein have strong interactions. The mechanism of quenching belongs to static quenching and the main sort of binding force is static-electricity gravitation.

引用

页码：1548 / 1550

页数：3