Using Scam to Investigate Reconfiguration of Molecular Determinants in D1-S6 during Slow Inactivation of hNav1.4

被引：0
|
作者：
Beard, Jon M. [1 ]
Shockett, Penny [1 ]
O'Reilly, John P. [1 ]
机构：
[1] Southeastern LA Univ, Dept Biol, Hammond, LA USA
来源：
BIOPHYSICAL JOURNAL | 2019年 / 116卷 / 03期
关键词：
D O I：
10.1016/j.bpj.2018.11.2108
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
1926-Pos
引用
收藏
页码：389A / 389A
页数：1
相关论文
共 9 条
  • [1] Substituted cysteine scanning in D1-S6 of the sodium channel hNav1.4 alters kinetics and structural interactions of slow inactivation
    Beard, Jonathan M.
    Shockett, Penny E.
    O'Reilly, John P.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2020, 1862 (02):
  • [2] In Search of a Molecular Mechanism for Slow Inactivation in Voltage-Gated Na Channels using the SCAM Technique in D2-S6 of hNav1.4
    O'Reilly, John P.
    Bokum, Kevin
    Beard, Jonathan
    Shockett, Penny
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 389A - 389A
  • [3] Effects of Cysteine Substitutions In D1-S6 on Fast and Slow Inactivation in Nav1.4
    O'Reilly, John
    Shockett, Penny
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 103A - 103A
  • [4] The S4 voltage sensors have differential role in kinetics of slow inactivation in hNav1.4 channels
    Vilin, YY
    McCollum, IJ
    Fujimoto, E
    Ruben, PC
    BIOPHYSICAL JOURNAL, 2003, 84 (02) : 215A - 216A
  • [5] Lysine substitution at V930 in D2-S6 of hNav1.5 greatly enhances slow inactivation
    Chancey, Jessica Hotard
    Shockett, Penny E.
    O'Reilly, John P.
    BIOPHYSICAL JOURNAL, 2007, : 102A - 102A
  • [6] Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels
    Szanto, Tibor G.
    Papp, Ferenc
    Zakany, Florina
    Varga, Zoltan
    Deutsch, Carol
    Panyi, Gyorgy
    JOURNAL OF GENERAL PHYSIOLOGY, 2023, 155 (07):
  • [7] Interaction of DPH with the local anesthetic receptor site in D1-S6 of the Na+ channel by NMR and molecular modeling
    Lou, Bih-Show
    Lin, Ta-Hsien
    UNDERSTANDING BIOLOGY USING PEPTIDES, 2006, : 174 - +
  • [8] Residue-specific effects on slow inactivation at V787 in D2-S6 of Nav1.4 sodium channels
    O'Reilly, JP
    Wang, SY
    Wang, GK
    BIOPHYSICAL JOURNAL, 2001, 81 (04) : 2100 - 2111
  • [9] Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6
    Chancey, Jessica Hotard
    Shockett, Penny E.
    O'Reilly, John P.
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 293 (06): : C1895 - C1905
1