House dust mite allergy and shrimp allergy: a complex interaction

被引：16

作者：

Celi, G. ^{[1
]}

Brusca, I ^{[2
]}

Scala, E. ^{[3
]}

Villalta, D. ^{[4
]}

Pastorello, E. ^{[5
]}

Farioli, L. ^{[6
]}

Cortellini, G. ^{[7
]}

Deleonardi, G. ^{[8
]}

Galati, P. ^{[8
]}

Losappio, L. ^{[5
]}

Manzotti, G. ^{[9
]}

Pirovano, B. ^{[10
]}

Muratore, L. ^{[11
]}

Murzilli, F. ^{[12
]}

Cucinelli, F. ^{[12
]}

Musarra, A. ^{[13
]}

Cilia, M. ^{[13
]}

Nucera, E. ^{[14
]}

Aruanno, A. ^{[14
]}

Ria, F. ^{[15
]}

Patria, M. F. ^{[15
]}

Varin, E. ^{[16
]}

Polillo, B. R. ^{[17
]}

Sargentini, V ^{[18
]}

Quercia, O. ^{[19
]}

Uasuf, C. G. ^{[20
]}

Zampogna, S. ^{[21
]}

Carollo, M. ^{[22
]}

Graci, S. ^{[23
]}

Asero, R. ^{[1
]}

机构：

[1] San Carlo Clin, Allergol Clin, Dugnano, MI, Italy

[2] Buccheri La Ferla FBF Hosp, UOC Clin Pathol, Palermo, Italy

[3] IDI IRCCS, Immacolata Dermopath Inst, Allergy Unit, Rome, Italy

[4] S Maria Angell Hosp, SSD Immunol & Allergol, Pordenone, Italy

[5] ASST GOM Niguarda, Complex Struct Allergol & Immunol, Milan, Italy

[6] ASST GOM Niguarda, Dept Lab Med, Milan, Italy

[7] Azienda Sanitaria Romagna, Allergol Clin, Operat Unit Internal Med Rimini, Rimini, Italy

[8] LUM AUSL, Bologna, Italy

[9] Beato Palazzolo Nursing Home, Allergol Serv, Bergamo, Italy

[10] ASST Bergamo Ovest, Lab Med Serv, Bergamo, Italy

[11] Lecce POV Fazzi ASL Clin, UOC Allergol & Immnol, Lecce, Italy

[12] SS Filippo & Nicola Hosp, UOSD Allergol, Avezzano, AQ, Italy

[13] Scillas Nursing Home, Allergol Serv, Scilla, RC, Italy

[14] Univ Hosp A Gemelli Fdn, Allergol Serv, Rome, Italy

[15] Univ Hosp A Gemelli Fdn, Gen Pathol Inst, Rome, Italy

[16] Maggiore Policlin Hosp, IRCCS Ca Granda Fdn, Pediat Area, Milan, Italy

[17] S Spirito & Nuovo Regina Margherita Hosp Ctr, Allergol Serv, UOC Internal Med, Rome, Italy

[18] S Filippo Neri Hosp, S Lab Allergol Serv, UOC Clin Pathol, Rome, Italy

[19] Faenza Hosp, Allergol Unit, Internal Med, Faenza, RA, Italy

[20] CNR, Biomed & Mol Immunol Inst, Allerg Dis Ctr Bonsignori, Palermo, Italy

[21] Ciaccio Apulian Hosp Co, Pediat Emergency Room, Catanzaro, Italy

[22] Magna Graecia Univ Catanzaro, Pathol & Biochem Clin, Catanzaro, Italy

[23] A Mirri Expt Zooprophylact Sicilys Inst, Palermo, Italy

来源：

EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY | 2020年 / 52卷 / 05期

关键词：

Food allergy; peach allergy; lipid transfer protein; SPT; diagnosis; ITALIAN ADULTS; TROPOMYOSIN;

D O I：

10.23822/EurAnnACI.1764-1489.108

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background and objective. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study. Methods. Shrimp sensitization and allergy were assessed in 526 house dust mite (HDM)-allergic patients submitted to the detection of IgE to Der p 10 and 100 atopic controls not sensitized to HDM. Results. Shrimp allergy occurred in 9% of patients (vs 0% of 100 atopic controls not sensitized to HDM; p < 0.001). Shrimp-allergic patients were less frequently hypersensitive to airborne allergens other than HDM than crustacean-tolerant subjects (35% vs 58.8%; p < 0.005). Only 51% of tropomyosin-sensitized patients had shrimp allergy, and these showed significantly higher Der p 10 IgE levels than shrimp-tolerant ones (mean 22.2 KU/l vs 6.2 KU/l; p < 0.05). Altogether 53% of shrimp-allergic patients did not react against tropomyosin. Conclusions. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients.

引用

页码：205 / 209

页数：5

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