In vitro activity of josamycin against Streptococcus pyogenes isolated from patients with upper respiratory tract infections in France

被引：1
|
作者：
Auzou, M. [1 ,2 ]
Caillon, J. [3 ]
Poyart, C. [4 ,5 ]
Weber, P. [6 ]
Ploy, M. -C. [7 ]
Leclercq, R. [1 ,2 ]
Cattoir, V. [1 ,2 ]
机构：
[1] CHU Caen, Microbiol Serv, F-14033 Caen 9, France
[2] CHU Caen, CNR Associe Resistance Antibiot, F-14033 Caen 9, France
[3] CHU Nantes, Serv Bacteriol Hyg, F-44093 Nantes, France
[4] Grp Hosp Cochin Port Royal Paul Broca, AP HP, Serv Bacteriol, F-75014 Paris, France
[5] Grp Hosp Cochin Port Royal Paul Broca, AP HP, CNR Streptocoques, F-75014 Paris, France
[6] Lab BIO VSM LAB, F-77360 Vaires Sur Marne, France
[7] CHU Limoges, Serv Bacteriol Virol Hyg, F-87042 Limoges, France
来源：
MEDECINE ET MALADIES INFECTIEUSES | 2015年 / 45卷 / 07期
关键词：
Group A Streptococcus (GAS); Macrolide resistance; S; pyogenes; MACROLIDE RESISTANCE; FRENCH CHILDREN; RING MACROLIDES; ERYTHROMYCIN; SUSCEPTIBILITY; MECHANISMS; PNEUMONIAE; EMERGENCE; STRAINS;
D O I：
10.1016/j.medmal.2015.04.009
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objectives. - The primary objective of our study was to obtain susceptibility data for josamycin against Streptococcus pyogenes isolated from patients presenting with upper respiratory tract infections in France. The secondary objective was to characterize the molecular mechanism of resistance in macrolide-resistant isolates. Patients and methods. - MICs of erythromycin, clarithromycin, azithromycin, josamycin, and clindamycin were determined by the broth microdilution method. Resistance genes erm(B), erm(TR), and mef(A) were screened by PCR. Results. - The MIC50 and MIC90 of josamycin against 193 isolates of S. pyogenes were 0.12 and 0.25 mg/L, respectively, with a resistance rate estimated at 4.7%. Resistance was due to the erm(B) gene whereas strains harboring erm(TR) or mef(A) remained susceptible. Conclusions. - Josamycin was active against >95% of S. pyogenes isolated from patients with upper respiratory tract infections, and can be used as an alternative for the treatment of pharyngitis. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：293 / 296
页数：4
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