The Secret Life of Smad4

被引：20
|
作者：
Wrana, Jeffrey L. [1 ,2 ]
机构：
[1] Mt Sinai Hosp, Ctr Syst Biol, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5G 1X5, Canada
来源：
CELL | 2009年 / 136卷 / 01期
关键词：
SYNAPTIC GROWTH; PATHWAY;
D O I：
10.1016/j.cell.2008.12.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Smad4 is an important mediator of signaling by TGF beta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.
引用
收藏
页码：13 / 14
页数：2
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